On the mechanism of complement fixation

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The Mechanism of Complement Fixation

1. Complement fixation is obtained in every antigen-antibody reaction involving the presence or formation of a heterogeneous phase (red cells, bacteria, precipitate). 2. The physical constants of fixation (temperature coefficient, velocity, quantitative relationships between the reactants) are those commonly associated with adsorption processes, and are the same in the three types of fixation s...

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Studies on Complement Fixation

It is shown by complement fixation studies with protein antigens and specific immune rabbit sera that the rate of fixation of complement is determined by the concentration of antibodies in the immune sera, that the greater part of fixation of complement takes place during the 1st hour, and that fixation is practically completed at the end of 4 hours at ice box temperature. It is further shown t...

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ژورنال

عنوان ژورنال: Zeitschrift für Chemie und Industrie der Kolloide

سال: 1913

ISSN: 0372-820X

DOI: 10.1007/bf01533538